LE-IHD program has supported the development of several living evidence synthesis from various organizations. With this free access repository, we support the evidence ecosystem by avoiding duplication of efforts between groups and we support the reuse of evidence in the processes of generation and adaptation of recommendations.

All the documents published in this repository have been peer-reviewed before its publication, are registered in the Open Science Framework, and its citation must include the corresponding DOI.

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Ongoing

Chimeric antigen receptor T cell therapy for hematological malignancies

Protocol

Baseline Report

Updated Reports

Evidence Surveillance

See in L.OVE

Publications

Saiz LC, Leache L… CAR-T therapy in hematologic malignancies

Effectiveness and safety of deep brain stimulation in severe and resistant Obsessive Compulsive Disorder

Protocol

Baseline Report

Evidence Surveillance

See in L.OVE

Publications

Genicular artery embolization in patients with knee pain secondary to osteoarthritis refractory to usual care

Protocol

Baseline Report

Updated Reports

Evidence Surveillance

See in L.OVE

Publications

Hernández-Yumar A, et al. Genicular artery embolization for knee osteoarthritis: a systematic review with meta-analysis and cost-analysis. Gac Sanit. 2025 Feb. doi: 10.1016/j.gaceta.2025.102459.

Pre-print registration Update: del Pino-Sedeño, T., Hernández, Y. G., de Armas-Castellano, A., Martin, M. T., & Rojas-Reyes, M. X., for The Living Evidence to Inform Health Decision Research Group (LE-IHD). (2025, August 11). Genicular artery embolization for the treatment of knee osteoarthritis: a living systematic evidence synthesis (Update report).

Effectiveness and safety of non-hospital cardiac rehabilitation (primary care, community, home) in patients with ischemic heart disease or heart failure

Protocol

Baseline Report

Updated Reports

Evidence Surveillance

See in L.OVE

Ischemic heart diseases

Heart failure

Publications

Pre-print registration Update: Duarte-Díaz, A., Álvarez-Pérez, Y., Santana, A. R., Perestelo-Perez, L., Martin, M. T., & Rojas-Reyes, M. X., for The Living Evidence to Inform Health Decision Research Group (LE-IHD). (2025, August 11). Effectiveness and safety of out-of-hospital cardiac rehabilitation: a living systematic review (Update report).

Cytoreductive surgery (CRS) giving together with hyperthermic intraperitoneal chemotherapy (HIPEC) in pediatric patients (<14 or 18 years) with peritoneal carcinomatosis

Protocol

Baseline Report

Evidence Surveillance

See in L.OVE

Publications

Pre-print registration Baseline: Ibargoyen-Roteta, N., Domínguez García, J., Jausoro, A., Galnares-Cordero, L., Rojas- Reyes, M. X., RN. for The Living Evidence to Inform Health Decision Research Group (LE-IHD). (2025, August 22). Cytoreductive Surgery (CRS) and Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) versus palliative chemotherapy in pediatric patients with peritoneal carcinomatosis (<18 years): a baseline report of a living systematic evidence synthesis.

Phophylaxis with vitamin D compared to placebo or no prophilaxis In patients at risk of SARS-Cov-2 infection or with mild, moderate or severe COVID-19.

Protocol

Baseline Report

Updated Reports

Evidence Surveillance

See in L.OVE

Covid

At risk of SARS-CoV-2 infection

Publications

Pre-print registration baseline: Sabalete, T., Blasco JA, Rodríguez R, Rosario MP, Rojas-Reyes MX for The Living Evidence to Inform Health Decision Research Group (LE-IHD). Efficacy and Safety of Vitamin D for COVID-19: A Living Evidence Synthesis Baseline report.

Biologic therapy (monoclonal antibodies) be given in combination with other interventions (LABA/LAMA; ICS, pulmonary rehabilitation) in adults with COPD

Protocol

Baseline Report

Evidence Surveillance

See in L.OVE

Publications

Pre-print registration baseline: Olga Milena García Morales, Ariadna Auladell, Daniel Poloni, Luz Angela Torres-López, Laura Díaz, Gerard Urrútia Couchi, María Ximena Rojas-Reyes. Biological Therapy for Chronic Obstructive Pulmonary Disease (COPD): Efficacy and Safety medRxiv 2025.10.17.25337825

Combined therapy vs monotherapy in treatment of hypertension in adults

Protocol

Baseline Report

Updated Reports

Evidence Surveillance

See in L.OVE

Publications

Glucagon-like peptide analogues and agonists in type II diabetes mellitus

Protocol

Baseline Report

Updated Reports

Evidence Surveillance

See in L.OVE

Publications

Detection and Management of MDR Bloodstream Infections and/or sepsis using Rapid Molecular diagnostics and Culture-Based Methods

Protocol

Baseline Report

Publications

Pre-print registration baseline: Rada, I., Gutiérrez Gómez, E., Benguria, G., Imeshtari, V., Ibargoyen-Roteta, N., Galnares-Cordero, L., & Rojas-Reyes, M. X., for The Living Evidence to Inform Health Decision Research Group (LE-IHD). (2025, August 22). Enhancing detection and management of bloodstream infection and/or sepsis caused by multi-drug resistant microorganisms integrating rapid molecular diagnostic tests and culture-based methods. A living Evidence Synthesis.

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Resolved

Fecal microbiota transplant for ulcerative colitis

Protocol

Baseline Report

Updated Report

See in L.OVE

Mechanical assist devices in cardiovascular diseases

Protocol

Baseline Report

Updated Report

See in L.OVE

Three-dimensional mammography for breast cancer

Protocol

Baseline Report

Updated Report

See in L.OVE

Bevacizumab, olaparib, rucaparib and niraparib for ovarian cancer

Protocol

Baseline Report

Updated Report

See in L.OVE

Bevacizumab

Olaparib

Niraparib

Rucaparib